Loneliness Linked to Increased Risk of Parkinson’s Disease

New research has shed light on the potential connection between loneliness and an increased risk of developing Parkinson’s disease. A study based on over 490,000 participants from the UK Biobank, who were observed for up to 15 years, revealed that individuals experiencing loneliness had a 37% higher chance of being diagnosed with Parkinson’s disease.

Angelina Sutin, the study’s senior researcher and a professor at Florida State University’s College of Medicine, emphasized that while there’s a noticeable correlation, it’s not necessarily a cause-and-effect relationship. “The association between loneliness and the development of Parkinson’s disease is evident. However, this doesn’t mean that loneliness directly causes Parkinson’s disease,” Sutin highlighted.

Loneliness is increasingly being recognized as a significant public health concern, with institutions like the U.S. Surgeon General, the National Academies of Sciences, Engineering and Medicine, and the World Health Organization pointing out its detrimental effects on health.

Furthermore, the study uncovers the broader impact of loneliness on brain health. Loneliness has previously been associated with conditions like Alzheimer’s disease and other forms of dementia. In this context, the recent research underscores loneliness as a potential risk factor for Parkinson’s as well. Loneliness might make the brain more susceptible to neurodegenerative conditions. This could manifest as Alzheimer’s for some, while others could develop Parkinson’s.

Elaborating on the mechanisms behind the link, Sutin explained that there might be several contributing factors, including behavioral, clinical, metabolic, inflammatory, and neuro-endocrine pathways. A singular, direct cause has yet to be identified. She also proposed the inverse: social connections might serve as a protective measure against Parkinson’s, though this hypothesis has yet to be thoroughly researched.

Experts also caution that living alone can sometimes lead to unhealthy lifestyle choices, which could potentially exacerbate the risk. Many older individuals living alone might not maintain a balanced diet or engage in regular physical activity. Additionally, the lack of daily brain stimulation due to loneliness might result in heightened stress levels, making the brain more vulnerable to various disorders.

The study underscores the importance of both physical and mental engagement in maintaining optimal brain health. Regular physical activity has been known to delay disease progression, and mental engagement can reduce the chances of cognitive issues.

In conclusion, while loneliness may not be a direct cause of Parkinson’s disease, its association with decreased brain health is undeniable. As researchers continue to delve deeper into this connection, it’s evident that fostering social connections and maintaining mental well-being is crucial for overall health.


Terracciano A, Luchetti M, Karakose S, Stephan Y, Sutin AR. Loneliness and Risk of Parkinson Disease. JAMA Neurol. Published online October 02, 2023. doi:10.1001/jamaneurol.2023.3382